9KC4 | pdb_00009kc4

The Cryo-EM structure of human succinate dehydrogenase in complex with Benzovindiflupyr

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity electron transfer activity	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process mitochondrial electron transport, succinate to ubiquinone aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development succinate metabolic process oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane nucleus membrane-enclosed lumen intracellular membraneless organelle nucleolus intracellular organelle lumen organelle lumen membraneless organelle nuclear lumen respiratory chain complex protein-containing complex catalytic complex respiratory chain complex II (succinate dehydrogenase) membrane protein complex oxidoreductase complex mitochondrial matrix
B	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	iron-sulfur cluster binding binding 3 iron, 4 sulfur cluster binding metal cluster binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity 2 iron, 2 sulfur cluster binding iron-sulfur cluster binding binding 3 iron, 4 sulfur cluster binding metal cluster binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity 4 iron, 4 sulfur cluster binding electron transfer activity 2 iron, 2 sulfur cluster binding quinone binding ubiquinone binding cation binding ion binding metal ion binding	ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribose phosphate metabolic process aerobic respiration cellular respiration oxidative phosphorylation ATP metabolic process energy derivation by oxidation of organic compounds ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process primary metabolic process generation of precursor metabolites and energy nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis metabolic process cellular process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process mitochondrial electron transport, succinate to ubiquinone aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport succinate metabolic process oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid metabolic process tricarboxylic acid cycle	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen respiratory chain complex protein-containing complex catalytic complex respiratory chain complex II (succinate dehydrogenase) membrane protein complex oxidoreductase complex mitochondrial matrix
C	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process mitochondrial electron transport, succinate to ubiquinone aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex respiratory chain complex II (succinate dehydrogenase) membrane protein complex oxidoreductase complex
D	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity electron transfer activity cation binding binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding oxidoreductase activity succinate dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor catalytic activity succinate dehydrogenase (quinone) activity electron transfer activity cation binding ion binding metal ion binding	aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds primary metabolic process metabolic process cellular process generation of precursor metabolites and energy ribose phosphate metabolic process oxidative phosphorylation ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process proton motive force-driven ATP synthesis nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process nucleobase-containing compound biosynthetic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process proton motive force-driven mitochondrial ATP synthesis nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process mitochondrial electron transport, succinate to ubiquinone aerobic electron transport chain ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport monoamine transport regulation of localization regulation of biological process nitrogen compound transport regulation of cellular process regulation of catecholamine secretion transport secretion regulation of transport biological regulation export from cell organic hydroxy compound transport establishment of localization regulation of secretion catecholamine secretion amine transport localization secretion by cell regulation of secretion by cell catecholamine transport regulation of amine transport response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex respiratory chain complex II (succinate dehydrogenase) membrane protein complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003953	FAD-dependent oxidoreductase 2, FAD-binding domain	Domain
A	IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal	Domain
A	IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site	Binding Site
A	IPR037099	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily	Homologous Superfamily
A	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR030664	FAD-dependent oxidoreductase SdhA/FrdA/AprA	Family
A	IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily	Homologous Superfamily
A	IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	Family
A	IPR011281	Succinate dehydrogenase, flavoprotein subunit	Family
B	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
B	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
B	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein	Family
B	IPR050573	Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur	Family
B	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
B	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
B	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal	Domain
B	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
B	IPR009051	Alpha-helical ferredoxin	Homologous Superfamily
B	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
C	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
C	IPR014314	Succinate dehydrogenase, cytochrome b556 subunit	Family
C	IPR018495	Succinate dehydrogenase, cytochrome b subunit, conserved site	Conserved Site
C	IPR000701	Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit	Family
D	IPR034804	Fumarate reductase/succinate dehydrogenase, transmembrane subunit	Homologous Superfamily
D	IPR007992	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	: P31040	Leigh syndrome gastrointestinal stromal tumor mitochondrial complex II deficiency, nuclear type 1 paraganglioma dilated cardiomyopathy paragangliomas 5 dilated cardiomyopathy 1GG cardiomyopathy LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY neuroendocrine carcinoma adrenal medulla cancer cancer left ventricular noncompaction osteoarthritis benign neoplasm of adrenal gland Leigh syndrome gastrointestinal stromal tumor mitochondrial complex II deficiency, nuclear type 1 paraganglioma dilated cardiomyopathy paragangliomas 5 dilated cardiomyopathy 1GG cardiomyopathy LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY neuroendocrine carcinoma adrenal medulla cancer cancer left ventricular noncompaction osteoarthritis benign neoplasm of adrenal gland phaeochromocytoma familial dilated cardiomyopathy inborn errors of metabolism leukodystrophy neurodegenerative disease osteoarthritis susceptibility 1 Carney triad schizophrenia dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy intellectual disability
B	: P21912	paraganglioma Carney-Stratakis syndrome gastrointestinal stromal tumor phaeochromocytoma Cowden disease paragangliomas 4 Cowden syndrome 2 Pheochromocytoma cancer mitochondrial complex II deficiency, nuclear type 1 neuroendocrine carcinoma rheumatoid arthritis adrenal gland pheochromocytoma ovarian cancer Sjogren syndrome paraganglioma Carney-Stratakis syndrome gastrointestinal stromal tumor phaeochromocytoma Cowden disease paragangliomas 4 Cowden syndrome 2 Pheochromocytoma cancer mitochondrial complex II deficiency, nuclear type 1 neuroendocrine carcinoma rheumatoid arthritis adrenal gland pheochromocytoma ovarian cancer Sjogren syndrome adrenal medulla cancer chronic obstructive pulmonary disease leukodystrophy multiple endocrine neoplasia type 2A pancreatic ductal adenocarcinoma benign neoplasm of adrenal gland Carney triad extra-adrenal sympathetic paraganglioma
C	: Q99643	gastrointestinal stromal tumor Cowden disease paragangliomas 3 Carney-Stratakis syndrome cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia paragangliomas 4 Pheochromocytoma adenoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor hereditary spastic paraplegia malignant glioma pancreatic ductal adenocarcinoma gastrointestinal stromal tumor Cowden disease paragangliomas 3 Carney-Stratakis syndrome cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia paragangliomas 4 Pheochromocytoma adenoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor hereditary spastic paraplegia malignant glioma pancreatic ductal adenocarcinoma paraganglioma pilocytic astrocytoma adrenal medulla cancer benign neoplasm of adrenal gland Carney triad large cell medulloblastoma neuroendocrine carcinoma pancreatic intraductal papillary-mucinous neoplasm phaeochromocytoma pituitary cancer allergic rhinitis glioblastoma malignant ependymoma medulloblastoma
D	: O14521	Carney-Stratakis syndrome mitochondrial complex II deficiency, nuclear type 1 paraganglioma melanoma phaeochromocytoma Cowden disease gastrointestinal stromal tumor paragangliomas 1 Pheochromocytoma jugulotympanic paraganglioma neuroendocrine carcinoma adrenal gland pheochromocytoma carotid body paraganglioma Cowden syndrome 3 cutaneous neuroendocrine carcinoma Carney-Stratakis syndrome mitochondrial complex II deficiency, nuclear type 1 paraganglioma melanoma phaeochromocytoma Cowden disease gastrointestinal stromal tumor paragangliomas 1 Pheochromocytoma jugulotympanic paraganglioma neuroendocrine carcinoma adrenal gland pheochromocytoma carotid body paraganglioma Cowden syndrome 3 cutaneous neuroendocrine carcinoma leprosy ovarian cancer adrenal medulla cancer breast cancer psoriasis carcinoid tumors, intestina multiple endocrine neoplasia type 2A pancreatic ductal adenocarcinoma benign neoplasm of adrenal gland cancer trabecular adenocarcinoma Cowden syndrome 2 cutaneous melanoma extra-adrenal sympathetic paraganglioma

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729. RCSB PDB uses resources of the National Energy Research Scientific Computing Center (NERSC), a Department of Energy User Facility.